St. Charles Borromeo Church is a Catholic church and second-oldest ecclesiastical parish in the Archdiocese of New Orleans. The church and grounds are located at 13396 River Road in Destrehan, Louisiana.

Destrehan is a census-designated place (CDP) in St. Charles Parish, Louisiana, United States. At the 2020 census, its population was 11,340. It is located on the east bank of the Mississippi River. Destrehan is part of the New Orleans—Metairie—Kenner metropolitan statistical area.