St. Francis College is a private Franciscan college in Downtown Brooklyn, New York City. It was founded in 1859 by the Franciscan Brothers of Brooklyn as the St. Francis Academy and was the first private school in the Diocese of Brooklyn. St. Francis College began as a parochial all-boys academy in the City of Brooklyn and has become a small liberal arts college that has 19 academic departments offering 72 majors and minors.

Downtown Brooklyn is the third largest central business district in New York City, and is located in the northwestern section of the borough of Brooklyn. The neighborhood is known for its office and residential buildings, such as the Williamsburgh Savings Bank Tower and the MetroTech Center office complex.