St. Leo is a town in Pasco County, Florida, United States. The town is a suburb included in the Tampa-St. Petersburg-Clearwater, Florida Metropolitan Statistical Area, which is more commonly known as the Tampa Bay area. It is best known as the home of St. Leo University, Holy Name Monastery and St. Leo Abbey. The population was 2,362 at the 2020 census. Vincent D'Ambrosio currently serves as the commission-elected mayor of the town, elected in 2022.

Pasco County is located on the west central coast of the U.S. state of Florida. According to the 2020 census, the population was 561,691. Its county seat is Dade City, and its largest city is Zephyrhills. The county is named after Samuel Pasco.