St. Mary Catholic Central High School, known colloquially as SMCC, is a Catholic, co-educational, parochial, secondary school located at 108 West Elm Avenue in Monroe, Michigan. SMCC is sponsored by the Catholic parishes of the Vicariate of Monroe under the auspices of the Roman Catholic Archdiocese of Detroit. The school itself is listed as a contributing property within the St. Mary's Church Complex Historic District.

Monroe is the largest city and county seat of Monroe County, Michigan, United States. The population was 20,462 as of the 2020 census. The city is bordered on the south by Monroe Charter Township, but the two are administered autonomously. Monroe is the core city in the Monroe metropolitan area, which is coterminous with Monroe County and had a population of 154,809 in 2020. Located on the western shores of Lake Erie approximately 20 miles (32 km) northeast of Toledo, Ohio, and 40 miles (64 km) southwest of Detroit, the city is part of the Detroit–Ann Arbor–Flint combined statistical area.