St Mary's Church is a Roman Catholic church in the city of Derby, England. A Grade II* listed building, it stands on Bridge Gate overlooking St Alkmund's Way. The church was designed by architect A. W. N. Pugin and according to Simon Jenkins, it is one of Pugin's "few complete works".

There are over 20,000 Grade II* listed buildings in England. This page is a list of these buildings in the City of Derby in Derbyshire.