Stoke Mandeville railway station serves the village of Stoke Mandeville, south of Aylesbury in Buckinghamshire, England. The station is on the London - Aylesbury line and is served by Chiltern Railways trains. It is between Wendover and Aylesbury stations.

Stoke Mandeville is a village and civil parish in the Vale of Aylesbury in Buckinghamshire, England. It is located three miles (4.9 km) from Aylesbury and 3.4 miles (5.5 km) from the market town of Wendover. Although a separate civil parish, the village falls within the Aylesbury Urban Area. According to the Census Report the area of this parish is 1,460 acres (5.9 km2).