A supercluster is a large group of smaller galaxy clusters or galaxy groups; they are among the largest known structures in the universe. The Milky Way is part of the Local Group galaxy group, which in turn is part of the Virgo Supercluster, which is part of the Laniakea Supercluster, which is part of the Pisces–Cetus Supercluster Complex. The large size and low density of superclusters means that they, unlike clusters, expand with the Hubble expansion. The number of superclusters in the observable universe is estimated to be 10 million.

A galaxy cluster, or a cluster of galaxies, is a structure that consists of anywhere from hundreds to thousands of galaxies that are bound together by gravity, with typical masses ranging from 1014 to 1015 solar masses. They are the second-largest known gravitationally bound structures in the universe after some superclusters (of which only one, the Shapley Supercluster, is known to be bound). They were believed to be the largest known structures in the universe until the 1980s, when superclusters were discovered. One of the key features of clusters is the intracluster medium (ICM). The ICM consists of heated gas between the galaxies and has a peak temperature between 2–15 keV that is dependent on the total mass of the cluster. Galaxy clusters should not be confused with galactic clusters (also known as open clusters), which are star clusters within galaxies, or with globular clusters, which typically orbit galaxies. Small aggregates of galaxies are referred to as galaxy groups rather than clusters of galaxies. The galaxy groups and clusters can themselves cluster together to form superclusters.