Swatara Creek is a 72-mile-long (116 km) tributary of the Susquehanna River in east-central Pennsylvania in the United States. It rises in the Appalachian Mountains in central Schuylkill County and passes through northwest Lebanon County before draining into the Susquehanna at Middletown in Dauphin County.

The Susquehanna River is a major river located in the Mid-Atlantic region of the United States, overlapping between the lower Northeast. At 444 miles (715 km) long, it is the longest river on the East Coast of the United States. By watershed area, it is the 16th-largest river in the United States, and also the longest river in the early 21st-century continental United States without commercial boat traffic.