Sylvester is a town in Boone County, West Virginia, United States, along the Big Coal River. The population was 166 at the 2020 census. Sylvester was incorporated on April 11, 1952, by the Boone County Circuit Court. Sylvester bears the name of a family of settlers.

Boone County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 21,809. Its county seat is Madison. Boone County is part of the Charleston, WV Metropolitan Statistical Area. Leading industries and chief agricultural products in Boone County include coal, lumber, natural gas, tobacco, and strawberries.