Synaptotagmin
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Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2 domains - C2A and C2B. There
Molecular machinery driving exocytosis in neurotransmitter release: the core SNARE complex (formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25) and the Ca2+ sensor synaptotagmin.
Complexin
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Complexin refers to a one of a small set of eukaryotic cytoplasmic neuronal proteins which binds to the SNARE protein complex with a high affinity. These are called synaphin 1 and 2. In the presence o
3-D structure of the Complexin/SNARE complex