"Take It on the Run" is a song by American rock band REO Speedwagon off the band's ninth studio album Hi Infidelity (1980). The song was written by lead guitarist Gary Richrath. "Take It on the Run" was the follow-up single behind the group's number-one hit, "Keep on Loving You". The single went gold on April 17, 1989. "Take It on the Run" has appeared on dozens of "various artists" compilation albums, as well as several REO Speedwagon greatest-hits albums. The 2017 song "Messin' Around" by Pitbull featuring Enrique Iglesias interpolates "Take It on the Run".

REO Speedwagon, or simply REO, is an American rock band from Champaign, Illinois. Formed in 1967, the band cultivated a following during the 1970s and achieved significant commercial success throughout the 1980s. Their best-selling album, Hi Infidelity (1980), contained four US Top 40 hits and sold more than 10 million copies.