The Teklanika River is a 91-mile (146 km) tributary of the Nenana River in the U.S. state of Alaska. The Nenana is a tributary of the Tanana River, which is part of the Yukon River drainage in the central interior region of the state. Flowing northward from headwaters at the Cantwell Glacier in the Alaska Range, the Teklanika drains an area widely visited by tourists to Denali National Park and Preserve. The park's only road crosses the river at milepost 31 and a National Park campground is located on its eastern bank at milepost 29.

The Tanana River is a 584-mile (940 km) tributary of the Yukon River in the U.S. state of Alaska. According to linguist and anthropologist William Bright, the name is from the Koyukon (Athabaskan) tene no, tenene, literally "trail river".