Tenacious D in The Pick of Destiny is a 2006 American musical fantasy comedy film about comedy rock duo Tenacious D. Written, produced by and starring Tenacious D members Jack Black and Kyle Gass, it is directed and co-written by musician and puppeteer Liam Lynch. Despite being about an actual band, the film is a fictitious story about the band's origins, and their journey to find a magical pick belonging to Satan that allows its users to become rock legends.

Tenacious D is an American comedy rock duo formed in Los Angeles, California, in 1994. It was founded by actors Jack Black and Kyle Gass, who were members of The Actors' Gang theater company at the time. The duo's name is derived from "tenacious defense", a phrase used by NBA basketball sportscasters Walt Frazier and Marv Albert. Backing members include John Konesky, John Spiker, and Scott Seiver. As a sort of a partial member, Dave Grohl has also recorded drums and percussion on all studio albums, but does not perform live.