State Highway 6 (SH 6) runs from the Red River, the Texas–Oklahoma state line, to northwest of Galveston, where it is known as the Old Galveston Highway. In Sugar Land and Missouri City, it is known as Alvin-Sugarland Road and runs perpendicular to Interstate 69/U.S. Highway 59 (I-69/US 59). In the Houston area, it runs north to Farm to Market Road 1960 (FM 1960), then northwest along US 290 to Hempstead, and south to Westheimer Road and Addicks, and is known as Addicks Satsuma Road. In the Bryan–College Station area, it is known as the Earl Rudder Freeway. In Hearne, it is known as Market Street. In Calvert, it is known as Main Street. For most of its length, SH 6 is not a limited-access road. In 1997, the Texas Legislature designated SH 6 as the Texas Korean War Veterans Memorial Highway.

Interstate 69 (I-69) is an Interstate Highway that is in the process of being built in the U.S. state of Texas. It is part of a longer I-69 extension known as the NAFTA superhighway, that, when completed, will connect Canada to Mexico. In Texas, it will connect Tenaha and the Louisiana segment of the route through the eastern part of the state and along the Texas Gulf Coast to Victoria, where it will split into three branches: I-69E to Brownsville, I-69C to Pharr, and I-69W to Laredo. The first segment of I-69 in Texas was opened in 2011 near Corpus Christi. The American Association of State Highway and Transportation Officials (AASHTO) approved an additional 58 miles (93 km) of U.S. Highway 77 (US 77) from Brownsville to the Willacy–Kenedy county line for designation as I-69, which was to be signed as I-69E upon concurrence from the Federal Highway Administration (FHWA). FHWA approval for this segment was announced on May 29, 2013. By March 2015, a 74.9-mile (120.5 km) section of US 59 had been completed and designated as I-69 through Greater Houston. As of 2024, short segments near the southern terminuses of the three branch routes have also all been completed. These branches are planned to be connected to the rest of the Interstate Highway System.