The Big Texan Steak Ranch is a steakhouse restaurant and motel located in Amarillo, Texas, United States, which opened on the previous U.S. Route 66 in the 4500 block of East Amarillo Boulevard in 1960. It relocated to its present location on Interstate 40 in 1970. Fire gutted the west wing of the restaurant in 1976 and destroyed $100,000 in antiques. The restaurant reopened as a larger facility in 1977. The building is painted a bright yellow, with blue trim. A large bull statue advertises their "free" 72 oz. steak. The now-closed Texas Tornado Museum resided off in a far corner of the parking lot on the property.

U.S. Route 66 or U.S. Highway 66 was one of the original highways in the United States Numbered Highway System. It was established on November 11, 1926, with road signs erected the following year. The highway, which became one of the most famous roads in the United States, ran from Chicago, Illinois, through Missouri, Kansas, Oklahoma, Texas, New Mexico, and Arizona before terminating in Santa Monica in Los Angeles County, California, covering a total of 2,448 miles (3,940 km).