The Cenci. A Tragedy, in Five Acts (1820) is a verse drama in five acts by Percy Bysshe Shelley written in the summer of 1819, and inspired by a real Roman family, the House of Cenci. Shelley composed the play in Rome and at Villa Valsovano near Livorno, from May to August 5, 1819. The work was published by Charles and James Ollier in London in 1819. The Livorno edition was printed in Livorno, Italy by Shelley himself in a run of 250 copies. Shelley told Thomas Love Peacock that he arranged for the printing himself because in Italy "it costs, with all duties and freightage, about half of what it would cost in London." Shelley sought to have the play staged, describing it as "totally different from anything you might conjecture that I should write; of a more popular kind... written for the multitude." Shelley wrote to his publisher Charles Ollier that he was confident that the play "will succeed as a publication." A second edition appeared in 1821, his only published work to go into a second edition during his lifetime.

Percy Bysshe Shelley was a British writer who is considered as one of the major English Romantic poets. A radical in his poetry as well as in his political and social views, Shelley did not achieve fame during his lifetime, but recognition of his achievements in poetry grew steadily following his death, and he became an important influence on subsequent generations of poets, including Robert Browning, Algernon Charles Swinburne, Thomas Hardy, and W. B. Yeats. American literary critic Harold Bloom describes him as "a superb craftsman, a lyric poet without rival, and surely one of the most advanced sceptical intellects ever to write a poem."