The Jay Leno Show is an American prime time talk show hosted by Jay Leno that was broadcast by NBC from September 14, 2009 to February 9, 2010. The series was a spiritual successor to his previous late-night talk show The Tonight Show with Jay Leno, and used a similar format consisting of a comedic monologue, followed by celebrity interviews and other comedy segments.

James Douglas Muir Leno is an American television host, writer and comedian. After doing stand-up comedy for years, he became the host of NBC's The Tonight Show from 1992 until 2009 when Conan O'Brien took over as host. Beginning in September 2009, Leno started a primetime talk show, The Jay Leno Show, which aired weeknights at 10:00 p.m. ET, also on NBC. When O'Brien turned down NBC's offer to have Leno host a half hour monologue show before The Tonight Show to boost ratings amid reported viewership diminishing, it led to the 2010 Tonight Show conflict which resulted in Leno returning to hosting the show on March 1, 2010. He hosted his last episode of his second tenure on February 6, 2014. That year, he was inducted into the Television Hall of Fame. From 2014 to 2022, he hosted Jay Leno's Garage, and from 2021 to 2023, hosted the revival of You Bet Your Life.