The Last Communion of St. Jerome is a 1614 oil-on-canvas painting by the Italian artist Domenichino. It was commissioned for the church of San Girolamo della Carità in Rome in 1612 and is now in the Pinacoteca Vaticana. The composition is very similar to a painting of the same subject by Agostino Carracci. Domenichino's rival, Giovanni Lanfranco, accused Domenichino of plagiarism due to the similarities.

Domenico Zampieri, known by the diminutive Domenichino after his shortness, was an Italian Baroque painter of the Bolognese School of painters.