The May Department Stores Company was an American department store holding company, formerly headquartered in downtown St. Louis, Missouri. It was founded in Leadville, Colorado, by David May in 1877, moving to St. Louis in 1905. After many changes in the retail industry, the company merged with Federated Department Stores in 2005.

Downtown St. Louis is the central business district of St. Louis, Missouri, the hub of tourism and entertainment, and the anchor of the St. Louis metropolitan area. The downtown is bounded by Cole Street to the north, the river front to the east, Chouteau Avenue to the south, and Tucker Boulevard to the west. The downtown is the site of many corporate headquarters, including Stifel Financial Corp., HOK, Spire Inc, and a host of other companies.