Thomas Culpeper was an English courtier and close friend of Henry VIII, and was related to two of his queens, Anne Boleyn and Catherine Howard. He is known to have had many private meetings with Catherine during her marriage, though these may have involved political intrigue rather than sex. A letter to him was found, written by Queen Catherine and signed, "Yours as long as life endures." Accused of adultery with Henry's young consort, Culpeper denied it and blamed the Queen for the situation, saying that he had tried to end his friendship with her, but that she was "dying of love for him". Eventually, Culpeper admitted that he intended to sleep with the queen, though he never admitted to having actually done so.

Henry VIII was King of England from 22 April 1509 until his death in 1547. Henry is known for his six marriages and his efforts to have his first marriage annulled. His disagreement with Pope Clement VII about such an annulment led Henry to initiate the English Reformation, separating the Church of England from papal authority. He appointed himself Supreme Head of the Church of England and dissolved convents and monasteries, for which he was excommunicated by the pope.