Thompson's Station is a town in Williamson County, Tennessee. The population has grown from 2,194 at the 2010 Census to 7,485 in the 2020 Census. Locations in Thompson's Station listed on the U.S. National Register of Historic Places include the Jacob Critz House and the Thomas L. Critz House, Thompson's Station Bank, John Neely House, James P. Johnson House, Homestead Manor and James Giddens House.

Williamson County is a county in the U.S. state of Tennessee. As of the 2020 United States census, the population was 247,726. The county seat is Franklin, and the county is located in Middle Tennessee. The county is named after Hugh Williamson, a North Carolina politician who signed the U.S. Constitution. Williamson County is part of the Nashville-Davidson–Murfreesboro–Franklin, TN Metropolitan Statistical Area. In the 19th century, tobacco and hemp were cultivated here, and planters also raised blooded livestock, including horses and cattle.