Trempealeau County is a county in the U.S. state of Wisconsin. As of the 2020 census, the population was 30,760. Its county seat is Whitehall.

The Driftless Area, also known as Bluff Country and the Paleozoic Plateau, is a topographical and cultural region in the Midwestern United States that comprises southwestern Wisconsin, southeastern Minnesota, northeastern Iowa, and the extreme northwestern corner of Illinois. The Driftless Area is a USDA Level III Ecoregion: Ecoregion 52. The Driftless Area takes up a large portion of the Upper Midwest forest–savanna transition. The Blufflands refers to the eastern section of the Driftless area in Minnesota, due to the steep bluffs and cliffs around the river valleys. The western half is known as the Rochester Plateau, which is flatter than the Blufflands. The Coulee Region refers to the southwestern part of the Driftless Area in Wisconsin. It is named for its numerous ravines.