Tri-State Airport is a public airport in Wayne County, West Virginia, United States, three miles south of Huntington, West Virginia, near Ceredo and Kenova. Owned by the Tri-State Airport Authority, it serves Huntington; Ashland, Kentucky; and Ironton, Ohio. It has heavy use for general aviation, and after the withdrawal of Delta Air Lines in June 2012, it was down to two airlines, one of which provides nationwide connecting service. In addition, there is one cargo airline flying to the airport, for a total of three commercial airlines serving it. On August 2, 2021, a federal subsidy was announced to subsidize flights to Washington-Dulles and Chicago-O'Hare airports. It is not yet known which airline will operate the flights.

Wayne County is the westernmost county in the U.S. state of West Virginia. As of the 2020 census, the population was 38,982. Its county seat is Wayne. The county was founded in 1842 and named for General "Mad" Anthony Wayne. Wayne County is part of the Huntington–Ashland, WV–KY–OH Metropolitan Statistical Area.