Tupelo is a city in and the county seat of Lee County, Mississippi, United States. With an estimated population of 38,300, Tupelo is the 7th most populous city in Mississippi and is considered a commercial, industrial, and cultural hub of North Mississippi.

Pontotoc County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 31,184. Its county seat is Pontotoc. It was created on February 9, 1836, from lands ceded to the United States under the Chickasaw Cession. Pontotoc is a Chickasaw word meaning "land of hanging grapes". The original Natchez Trace and the current-day Natchez Trace Parkway both pass through the southeast corner of Pontotoc County.