Tupelo, genus Nyssa, is a small genus of deciduous trees with alternate, simple leaves. It is sometimes included in the subfamily Nyssoideae of the dogwood family, Cornaceae, but is placed by other authorities in the family Nyssaceae. In the APG IV system, it is placed in Nyssaceae.

Tupelo is a city in and the county seat of Lee County, Mississippi, United States. With an estimated population of 38,300, Tupelo is the 7th most populous city in Mississippi and is considered a commercial, industrial, and cultural hub of North Mississippi.