The Tupelo Micropolitan Statistical Area is a micropolitan area in northeastern Mississippi that covers three counties—Itawamba, Lee and Pontotoc. As of the 2000 census, the area had a population of 125,251. The population at the 2020 Census was 138,390.

Itawamba County is a county located in the U.S. state of Mississippi. As of the 2020 United States Census, the population was 23,863. Its county seat is Fulton. The county is part of the Tupelo, MS Micropolitan Statistical Area.