U.S. Bank Center is a skyscraper located in downtown Milwaukee, Wisconsin, noted for being the tallest building in the state of Wisconsin, and the tallest building between Chicago and Minneapolis. Standing 601 feet (183 m) and 42 stories tall, the building has a floor area of 1,077,607 sq ft (100,113.0 m2) and it surpassed the Milwaukee City Hall as the tallest building in both the city and the state. Topped off August 29, 1972, and completed in 1973, it was the headquarters for what eventually became Firstar Corporation from 1973 to 2001. The building was designed by Colombian-Peruvian architect Bruce Graham with James DeStefano of Skidmore, Owings & Merrill, and engineered by Bangladeshi-American structural engineer Fazlur Rahman Khan. As of 2017, the building is home to the headquarters of Foley & Lardner, Robert W. Baird & Company, Sensient Technologies Corporation, and is the Milwaukee office for U.S. Bank, IBM, and CBRE.

The Milwaukee City Hall is a skyscraper and town hall located in Milwaukee, Wisconsin, United States. It was finished in 1895, and was Milwaukee's tallest building until completion of the First Wisconsin Center in 1973. In 1973 it was listed on the National Register of Historic Places.