U.S. Highway 10 (US 10) in Wisconsin runs east–west across the central part of the state. It runs from the Prescott Drawbridge over the St. Croix River at Prescott east to the dock in Manitowoc where SS Badger crosses Lake Michigan to Ludington, Michigan. The highway is also designated as the Vietnam War Veterans Memorial Highway for its entire length.

Prescott is a city in Pierce County, Wisconsin at the confluence of the St. Croix River and Mississippi River. The population was 4,258 at the 2010 census, making it the second-largest city in the county after River Falls, and the largest entirely within Pierce County.