U.S. Route 11 (US 11) runs southwest to northeast across northcentral Alabama for 250.671 miles (403.416 km). It enters the state from Mississippi concurrent with US 80 and exits into Georgia east of Sulphur Springs. US 11 runs through the major cities of Tuscaloosa and Birmingham, as well as the smaller cities and towns of Cuba, York, Livingston, Epes, Boligee, Eutaw, Cottondale, Coaling, Woodstock, Bessemer, Brighton, Midfield, Trussville, Argo, Springville, Ashville, Steele, Attalla, Reece City, and Collinsville. State Route 7 (SR 7) is designated along the entire route but unsigned.

U.S. Route 80 (US 80) is a major U.S. Highway in the American state of Alabama. The Alabama Department of Transportation internally designates the majority of US 80 throughout the state as State Route 8 (SR 8), save for parts of the route throughout Selma and near the Mississippi border. Serving as the main east to west highway through Alabama's Black Belt region, US 80 became well known as the main route for the 1965 Selma to Montgomery marches; it was the route along which the Civil Rights demonstrators walked, from Selma to Alabama, and the Edmund Pettus Bridge in Selma was the site of Bloody Sunday. The highway was also once a major transcontinental highway reaching from Tybee Island, Georgia, to San Diego, California, but has since been truncated to Dallas, Texas because it was largely replaced by the Interstate Highway System.