U.S. Route 13 (US 13) is a United States Numbered Highway running from Fayetteville, North Carolina, north to Morrisville, Pennsylvania. In the U.S. state of Maryland, the route runs 42.48 miles (68.36 km) from the Virginia border south of Pocomoke City in Worcester County north to the Delaware border in Delmar, Wicomico County, where the route intersects Maryland Route 54 (MD 54)/Delaware Route 54 (DE 54), which runs along the state line. The majority of the route within Maryland is a four-lane divided highway that passes through rural areas of woodland and farmland. The route also runs through a few municipalities including Pocomoke City and Princess Anne and it bypasses Fruitland and Salisbury to the east on the Salisbury Bypass, which is a freeway. US 13 intersects many major roads including the southern terminus of US 113 in Pocomoke City, MD 413 in Westover, and MD 12 and US 50 where the route is on the Salisbury Bypass. The route shares a concurrency with US 50 along a portion of the Salisbury Bypass.

Worcester County is the easternmost county of the U.S. state of Maryland. As of the 2020 census, the population was 52,460. Its county seat is Snow Hill.