U.S. Route 13 (US 13) is a north–south United States Numbered Highway established in 1926 that runs for 518 miles (834 km) from Interstate 95 (I-95) just north of Fayetteville, North Carolina, north to US 1 in Morrisville, Pennsylvania, a northeastern suburb of Philadelphia. In the U.S. state of Virginia, US 13 runs north–south through the Hampton Roads and Eastern Shore regions of the state, using the Chesapeake Bay Bridge–Tunnel to get between the two. In the Hampton Roads area, it uses Military Highway to bypass the city centers. It is most usually a four-lane highway, sometimes up to freeway or expressway standards with controlled access.

The Eastern Shore of Virginia is the easternmost region of the Commonwealth of Virginia in the United States. It consists of two counties on the Atlantic coast. It is detached from the mainland of Virginia by the Chesapeake Bay. The 70-mile-long (110 km) region is part of the Delmarva Peninsula. Its population was 45,695 as of 2020.