U.S. Highway 17 (US 17) in Florida is a north–south United States Numbered Highway that runs 317 miles (510 km) from the Punta Gorda, Florida Metropolitan Statistical Area northeast to the Jacksonville metropolitan area.

The Jacksonville Metropolitan Area, also called the First Coast, Metro Jacksonville, or Northeast Florida, is the metropolitan area centered on the principal city of Jacksonville, Florida and including the First Coast of North Florida. As of the 2020 United States census, the total population was 1,605,848. The Jacksonville–Kingsland–Palatka, FL–GA Combined Statistical Area (CSA) had a population of 1,733,937 in 2020 and was the 34th largest CSA in the United States. The Jacksonville metropolitan area is the 40th largest in the country and the fourth largest in the State of Florida, behind the Miami, Tampa, and Orlando metropolitan areas.