U.S. Route 290 is an east–west U.S. Highway located entirely within the state of Texas. Its western terminus is at Interstate 10 southeast of Segovia, and its eastern terminus is at Interstate 610 in northwest Houston. It is the main highway between Houston and Austin and is a cutoff for travelers wanting to bypass San Antonio on Interstate 10. Throughout its length west of Austin, US 290 cuts across mountainous hills comprising the Texas Hill Country and the Edwards Plateau; between Austin and Houston, the highway then travels through gradually hilly grasslands and pine forests comprising the Gulf Coastal Plains.

Interstate 10 (I-10) is the major east–west Interstate Highway in the Southern United States. In the U.S. state of Texas, it runs east from Anthony, at the border with New Mexico, through El Paso, San Antonio, and Houston to the border with Louisiana in Orange. At just under 880 mi (1,420 km), the Texas segment of I-10, maintained by the Texas Department of Transportation, is the longest continuous untolled freeway in North America that is operated by a single authority. It is also the longest stretch of Interstate Highway with a single designation within a single state. Mile marker 880 and its corresponding exit number in Orange, Texas, are the highest-numbered mile marker and exit on any freeway in North America. Since widening was completed in 2008, a portion of the highway west of Houston is now also believed to be the widest in the world, at 26 lanes when including feeders.