U.S. Route 40 enters Pennsylvania at West Alexander. It closely parallels Interstate 70 (I-70) from West Virginia until it reaches Washington, where it follows Jefferson Avenue and Maiden Street. In Washington, US 40 passes to the south of Washington & Jefferson College. Following Maiden Street out of town, the road turns southeast toward the town of California. A short limited access highway in California and West Brownsville provides an approach to the Lane Bane Bridge across the Monongahela River. From here, the road continues southeast to Uniontown.

Interstate 70 (I-70) is a state highway that is located in the Commonwealth of Pennsylvania in the United States. It runs east to west across the southwest part of Pennsylvania and serves the southern fringe of the Pittsburgh metropolitan area.