US Highway 41 (US 41) is a part of the United States Numbered Highway System that runs from Miami, Florida, to the Upper Peninsula of the US state of Michigan. In Michigan, it is a state trunkline highway that enters the state via the Interstate Bridge between Marinette, Wisconsin, and Menominee, Michigan. The 278.769 miles (448.635 km) of US 41 that lie within Michigan serve as a major conduit. Most of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane divided expressway and the Copper Country Trail National Scenic Byway. The northernmost community along the highway is Copper Harbor at the tip of the Keweenaw Peninsula. The trunkline ends at a cul-de-sac east of Fort Wilkins State Park after serving the Central Upper Peninsula and Copper Country regions of Michigan.

The Keweenaw Peninsula is the northernmost part of Michigan's Upper Peninsula. It projects into Lake Superior and was the site of the first copper boom in the United States, leading to its moniker of "Copper Country." Its major industries are now logging and tourism, as well as jobs related to Michigan Technological University.