US Highway 41 (US 41) is a part of the United States Numbered Highway System that runs from Miami, Florida, to the Upper Peninsula of the US state of Michigan. In Michigan, it is a state trunkline highway that enters the state via the Interstate Bridge between Marinette, Wisconsin, and Menominee, Michigan. The 278.769 miles (448.635 km) of US 41 that lie within Michigan serve as a major conduit. Most of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane divided expressway and the Copper Country Trail National Scenic Byway. The northernmost community along the highway is Copper Harbor at the tip of the Keweenaw Peninsula. The trunkline ends at a cul-de-sac east of Fort Wilkins State Park after serving the Central Upper Peninsula and Copper Country regions of Michigan.

Menominee is a city and the county seat of Menominee County, Michigan in the Upper Peninsula. The population was 8,488 at the 2020 census. It is the county seat of Menominee County. Menominee is the fourth-largest city in the Upper Peninsula, behind Marquette, Sault Ste. Marie, and Escanaba. Menominee Township is located to the north of the city, but is politically autonomous.