U.S. Route 52 (US 52) is a north–south United States highway that runs for 150 miles (240 km) from the South Carolina state line, near McFarlan, to the Virginia state line, near Mount Airy. It serves as a strategic highway through the central North Carolina Piedmont. Because of its alignment in the state, US 52 does not follow the standard convention of an even U.S. route number going east–west.

Anson County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 22,055. Its county seat is Wadesboro.