U.S. Route 54 is a part of the U.S. Highway System that runs from El Paso, Texas, to Interstate 72 (I-72) in Griggsville, Illinois. In the U.S. state of Kansas, US 54 is a main east–west highway that runs from the Oklahoma border east to the Missouri border.

U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri. In the state of Kansas, US-160 is a main east–west highway that runs from the Colorado border east to the Missouri border.