U.S. Highway 61 (US 61) is a United States Highway that serves eastern Iowa. It enters the state from Missouri near Keokuk with US 136. North of Keokuk, it is overlapped by US 218 for a few miles. It the follows the course of the Mississippi River past Montrose and Fort Madison. It meets US 34 at Burlington. It passes through Wapello and bypasses Muscatine and Blue Grass on its way toward Davenport. There, it follows Interstate 280 (I-280) and I-80 around the Quad Cities. North of Davenport, it follows a freeway north toward DeWitt where it meets US 30. The highway continues north through Maquoketa and reaches the Dubuque area. There it is joined by US 151 and briefly by US 52. The two highways enter the downtown area on an expressway. Due to the proximity of the Mississippi River and railroad tracks that lie between, the routes have an indirect junction with US 20. The two highways leave the state and enter Wisconsin about one-half mile (800 m) north of the Illinois–Wisconsin state line.

U.S. Highway 136 (US 136) is a short U.S. Highway in Keokuk, Iowa. The route was designated nationally in 1951 and has remained largely unchanged through Keokuk since then. The highway originally crossed the Mississippi on the Keokuk Rail Bridge, which was the second bridge built and operated by Andrew Carnegie's Keokuk & Hamilton Bridge Company in that location. While it was designed for wagons and early automobiles, crossing the rail bridge became difficult in larger modern vehicles, specifically semi trucks. As a result, a new automobile-only bridge was built directly to the south of the older span. The Keokuk–Hamilton Bridge opened in 1985 eight months early and under budget.