U.S. Route 62 (US 62) in Kentucky runs for a total of 391.207 miles (629.587 km) across 20 counties in western, north-central, and northeastern Kentucky. It enters the state by crossing the Ohio River near Wickliffe, then begins heading eastward at Bardwell, and traversing several cities and towns across the state up to Maysville, where it crosses the Ohio River a second time to enter the state of Ohio.

Paducah is a home rule-class city in and the county seat of McCracken County, Kentucky, United States. The largest city in the Jackson Purchase region, it is located in the Southeastern United States at the confluence of the Tennessee and the Ohio rivers, halfway between St. Louis, Missouri, to the northwest and Nashville, Tennessee, to the southeast. As of the 2020 census, the population was 27,137, up from 25,024 in 2010. Twenty blocks of the city's downtown have been designated as a historic district and listed on the National Register of Historic Places.