In Oklahoma, U.S. Highway 62 (US 62) runs diagonally across the state, from the Texas state line in far southwestern Oklahoma to the Arkansas state line near Fayetteville. US-62 spends a total of 402.48 miles (647.73 km) in the Sooner State. The highway passes through fifteen of Oklahoma's counties. Along the way the route serves two of Oklahoma's largest cities, Lawton and Oklahoma City, as well as many regionally important cities, like Altus, Chickasha, Muskogee, and Tahlequah. Despite this, US-62 has no lettered spur routes like many other U.S. routes in Oklahoma do.

Lawton is a city in and the county seat of Comanche County, in the U.S. state of Oklahoma. Located in southwestern Oklahoma, approximately 87 mi (140 km) southwest of Oklahoma City, it is the principal city of the Lawton, Oklahoma, metropolitan statistical area. According to the 2020 census, Lawton's population was 90,381, making it the sixth-largest city in the state, and the largest in Western Oklahoma.