U.S. Route 66 also known as the Will Rogers Highway, was a major United States Numbered Highway in the state of Arizona from November 11, 1926, to June 26, 1985. US 66 covered a total of 385.20 miles (619.92 km) through Arizona. The highway ran from west to east, starting in Needles, California, through Kingman and Seligman to the New Mexico state line. Nationally, US 66 ran from Santa Monica, California, to Chicago, Illinois. In its height of popularity, US 66 was one of the most popular highways in the state of Arizona, sometimes carrying over one million cars a year.

U.S. Route 93 (US 93) is a United States Numbered Highway in the state of Arizona that begins in Wickenburg and heads north to the Nevada state line at the Mike O'Callaghan–Pat Tillman Memorial Bridge. The total length of US 93 in Arizona is 199.38 miles. Between Wickenburg and Interstate 40 (I-40), part of US 93 is designated as the Joshua Forest Scenic Byway. While most of US 93 is a four-lane divided highway, sections of the highway between Wickenburg and I-40 are still narrow two-lane roads, gradually being upgraded to match the rest of the route. As part of a proposal by municipal leaders in Nevada and Arizona, the highway could be replaced by Interstate 11 (I-11).