U.S. Route 6 (US 6) is a part of the United States Numbered Highway System that runs from Bishop, California, to Provincetown, Massachusetts. In Ohio, the road runs west–east from the Indiana state line near Edgerton to the Pennsylvania state line near Andover. The 248.002 miles (399.121 km) that lie in Ohio are maintained by the Ohio Department of Transportation (ODOT). US 6 serves the major cities of Sandusky, Lorain, and Cleveland. The highway is also called the Grand Army of the Republic Highway to honor the Union forces of the U.S. Civil War. The alternate name was designated in 1953.

U.S. Route 23 (US 23) is a United States Numbered Highway that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In the state of Ohio, it is a major north–south state highway that runs from the Kentucky border at Portsmouth to the Michigan border at Sylvania.