U.S. Route 6 (US 6) is a part of the United States Numbered Highway System that runs from Bishop, California, to Provincetown, Massachusetts. In Ohio, the road runs west–east from the Indiana state line near Edgerton to the Pennsylvania state line near Andover. The 248.002 miles (399.121 km) that lie in Ohio are maintained by the Ohio Department of Transportation (ODOT). US 6 serves the major cities of Sandusky, Lorain, and Cleveland. The highway is also called the Grand Army of the Republic Highway to honor the Union forces of the U.S. Civil War. The alternate name was designated in 1953.

State Route 49 is a state highway in the western part of the U.S. state of Ohio. It begins in Drexel, an area within the city of Trotwood, at US 35 and runs northwesterly to Greenville, and then runs roughly along near the western edge of the state near the Indiana state line to the Michigan state line where it meets with Michigan's M-49.