U.S. Route 73 is a north–south United States highway that runs for 113 miles (182 km) from northeast Kansas to southeast Nebraska. The highway's southern terminus is Bonner Springs, Kansas at I-70. Its northern terminus is near Dawson, Nebraska at US 75.

The United States Numbered Highway System is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these highways were coordinated among the states, they are sometimes called Federal Highways, but the roadways were built and have always been maintained by state or local governments since their initial designation in 1926.