U.S. Route 79 enters Kentucky from Tennessee in Todd County west of Guthrie and runs northeast into Logan County, terminating at a junction with US 68, US 68 Business, and Kentucky Route 80 in Russellville. US 79 remains a two-lane road throughout Kentucky.

U.S. Route 68 is a United States highway that runs for 560 miles (900 km) from northwest Ohio to Western Kentucky. The highway's western terminus is at US 62 in Reidland, Kentucky. Its present northern terminus is at Interstate 75 in Findlay, Ohio, though the route once extended as far north as Toledo. US 68 intersects with US 62 three times during its route.