U.S. Route 80 (US 80), also known as the Ocean-to-Ocean Highway, the Broadway of America and the Jefferson Davis Memorial Highway, was a major transcontinental highway that existed in the U.S. state of Arizona from November 11, 1926, to October 6, 1989. At its peak, US 80 traveled from the California border in Yuma to the New Mexico state line near Lordsburg. US 80 was an important highway in the development of Arizona's car culture. Like its northern counterpart, US 66, the popularity of travel along US 80 helped lead to the establishment of many unique roadside businesses and attractions, including many iconic motor hotels and restaurants. US 80 was a particularly long highway, reaching a length of almost 500 miles (800 km) within the state of Arizona alone for most of the route's existence.

U.S. Route 66 also known as the Will Rogers Highway, was a major United States Numbered Highway in the state of Arizona from November 11, 1926, to June 26, 1985. US 66 covered a total of 385.20 miles (619.92 km) through Arizona. The highway ran from west to east, starting in Needles, California, through Kingman and Seligman to the New Mexico state line. Nationally, US 66 ran from Santa Monica, California, to Chicago, Illinois. In its height of popularity, US 66 was one of the most popular highways in the state of Arizona, sometimes carrying over one million cars a year.