U.S. Route 95 is a major U.S. highway traversing the U.S. state of Nevada from north to south directly through Las Vegas and providing connections to both Carson City and Reno. US 95 is cosigned with Interstate 80 for 95 miles (153 km) between a junction in Trinity and Winnemucca before heading north into Oregon at McDermitt. At 646.71 miles (1,040.78 km), it is the longest highway in Nevada.

U.S. Route 50 (US 50) is a transcontinental highway in the United States, stretching from West Sacramento, California, in the west to Ocean City, Maryland, on the east coast. The Nevada portion crosses the center of the state and was named "The Loneliest Road in America" by Life magazine in July 1986. The name was intended as a pejorative, but Nevada officials seized it as a marketing slogan. The name originates from large desolate areas traversed by the route, with few or no signs of civilization. The highway crosses several large desert valleys separated by numerous mountain ranges towering over the valley floors, in what is known as the Basin and Range province of the Great Basin.