UPS Airlines is a major American cargo airline based in Louisville, Kentucky. One of the largest cargo airlines worldwide, UPS Airlines flies to 815 destinations worldwide. It has been a wholly owned subsidiary of United Parcel Service since its launch in 1988.

Cargo airlines are airlines mainly dedicated to the transport of cargo by air. Some cargo airlines are divisions or subsidiaries of larger passenger airlines. In 2018, airline cargo traffic represented 262,333 million tonne-kilometres with a 49.3% load factor: 52.1% for dedicated cargo operations, and 47.9% within mixed operations.