USS James E. Williams (DDG-95) is a Flight IIA Arleigh Burke-class destroyer in the United States Navy. The ship was named for Boatswain's mate Petty officer first class James Eliott Williams (1930–1999), a River Patrol Boat commander and Medal of Honor recipient from the Vietnam War who is considered to be the most decorated enlisted man in Navy history. As of April 2023 the ship is part of Destroyer Squadron 26 based out of Naval Station Norfolk.

The Arleigh Burke class of guided-missile destroyers (DDGs) is a United States Navy class of destroyer centered around the Aegis Combat System and the SPY-1D multi-function passive electronically scanned array radar. The class is named for Admiral Arleigh Burke, an American destroyer officer in World War II and later Chief of Naval Operations. With an overall length of 505 to 509.5 feet, displacement ranging from 8,300 to 9,700 tons, and weaponry including over 90 missiles, the Arleigh Burke-class destroyers are larger and more heavily armed than many previous classes of guided-missile cruisers.