USS Michael Murphy (DDG-112) is the 62nd ship of the Arleigh Burke class of guided missile destroyers in the United States Navy. She is named for Medal of Honor recipient Lieutenant Michael P. Murphy (1976–2005). Murphy was posthumously awarded the Medal of Honor for his actions during Operation Red Wings in Afghanistan in June 2005. He was the first sailor awarded the Medal of Honor since the Vietnam War. The ship's name was announced by Secretary of the Navy, Donald C. Winter on 7 May 2008. The ship was christened on 7 May 2011, Murphy's birthday, by her sponsor Maureen Murphy, Michael Murphy's mother. The ship is part of Destroyer Squadron 31 of Naval Surface Group Middle Pacific.

The Arleigh Burke class of guided-missile destroyers (DDGs) is a United States Navy class of destroyer centered around the Aegis Combat System and the SPY-1D multi-function passive electronically scanned array radar. The class is named for Admiral Arleigh Burke, an American destroyer officer in World War II and later Chief of Naval Operations. With an overall length of 505 to 509.5 feet, displacement ranging from 8,300 to 9,700 tons, and weaponry including over 90 missiles, the Arleigh Burke-class destroyers are larger and more heavily armed than many previous classes of guided-missile cruisers.