USS Thresher (SSN-593) was the lead boat of her class of nuclear-powered attack submarines in the United States Navy. She was the U.S. Navy's second submarine to be named after the thresher shark.

The Permit-class submarine was a class of nuclear-powered fast attack submarines in service with the United States Navy from the early 1960s until 1996. They were a significant improvement on the Skipjack class, with greatly improved sonar, diving depth, and silencing. They were the forerunners of all subsequent US Navy SSN designs. They served from the 1960s through to the early 1990s, when they were decommissioned due to age. They were followed by the Sturgeon and Los Angeles classes.